Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5676251 | American Journal of Obstetrics and Gynecology | 2017 | 26 Pages |
Abstract
The Prospective Observational Trial to Optimize Pediatric Health in Intrauterine Growth Restriction group previously demonstrated that the presence of a brain-sparing effect was significantly associated with an adverse perinatal outcome in our intrauterine growth restriction cohort. It was hypothesized that a normalizing cerebroplacental ratio would be a further predictor of an adverse outcome due to the loss of this compensatory mechanism. However, in this subanalysis we did not demonstrate an additional poor prognostic effect when the cerebroplacental ratio value returned to a value >1.0. Overall, this secondary analysis demonstrated the importance of a serial abnormal cerebroplacental ratio value of <1 within the <34 weeks' gestation population. Contrary to our proposed hypothesis, we recognize that reversion of an abnormal cerebroplacental ratio to a normal ratio is not associated with a heightened degree of adverse perinatal outcome.
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Authors
Cathy MRCPI, Karen MD, Sieglinde MRCPI, Julia PhD, Fionnuala MD, Sean MD, Michael P. MD, Mairead M. MD, Fionnuala M. MD, Keelin PhD, Alison MD, John J. MD, Gerald FRCOG, Patrick PhD, Elizabeth C. PhD, Fergal D. MD,