Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5676259 | American Journal of Obstetrics and Gynecology | 2017 | 8 Pages |
Abstract
Chronic first-trimester ethanol exposure significantly reduces placental perfusion and oxygen supply to the fetal vasculature later in pregnancy. These perturbations of placental function are associated with fetal growth impairments. However, differences between ethanol-exposed and control animals in placental function and fetal developmental outcomes were smaller at gestational day 135 than at gestational day 110. These findings are consistent with placental adaptation to early perturbations that allow for compensated placental function and maintenance of fetal growth.
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Authors
Jamie O. MD, Matthias C. PhD, Victoria H.J. PhD, Xiaojie PhD, Katherine S. BS, Kathleen A. PhD, Antonio E. MD, Christopher D. PhD,