| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5676350 | American Journal of Obstetrics and Gynecology | 2017 | 46 Pages |
Abstract
Collectively, our data uncover a novel link between the anaerobic glycolysis and the control of uterine inflammation wherein the high levels of lactate produced during labor act on uterine GPR81 to down-regulate key proinflammatory genes. This discovery may represent a novel feedback mechanism to regulate inflammation during labor, and conveys a potential rationale for the use of GPR81 agonists to attenuate inflammation and resulting preterm birth.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Medicine and Dentistry (General)
Authors
Ankush BPharm, MSc, Mathieu BSc, Jose Carlos PhD, Dima MSc, Xin MD, PhD, Estefania Marin BSc, Sylvie PhD, David M. PhD, Sylvain MD, PhD,