Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5678190 | Chronic Diseases and Translational Medicine | 2017 | 8 Pages |
Abstract
Anti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a “dormant” disease. However, the combination of anti-angiogenesis agents with conventional therapeutics has generally produced only modest survival benefits for cancer patients in clinical trials. Therefore, the concept and applications of anti-angiogenesis have evolved dramatically along with lessons learned from recent clinical experience. In this article, we will discuss the revised concept of anti-angiogenesis therapy and the applications of anti-angiogenesis drugs, and focus particularly on how to utilize current anti-angiogenesis agents and develop new approaches to provide more benefits to patients with cancer.
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Authors
Wen-Hui Yang, Jun Xu, Jian-Bing Mu, Jun Xie,