Article ID Journal Published Year Pages File Type
5681285 Medicine 2017 5 Pages PDF
Abstract
Anticoagulant therapy using heparins and vitamin K antagonists has been used effectively for prevention and treatment of thromboembolic events for many years. However, therapy is associated with a significant risk of haemorrhagic complications, warranting careful consideration of the need for anticoagulation. Recognized drawbacks of current anticoagulants are their unpredictable pharmacokinetics and the need for laboratory monitoring, which have led in recent years to the development of direct oral anticoagulant agents.
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