Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5684958 | Translational Research | 2017 | 11 Pages |
Abstract
Development of chimeric antigen receptor (CAR) T cells have led to remarkable successes in the treatment of B-cell malignancies with anti-CD19 CAR. Here we discuss the development of novel antigen receptors for use in solid malignancies with respect to target antigens, receptor design, and T cell manipulations.
Keywords
NCI CTCAENSGNOD SCID gammascFvTCrPBLHuman leukocyte antigenHLARECISTSingle chain variable fragmentperipheral blood lymphocytesNational Cancer Institute Common Terminology Criteria for Adverse EventsCARmajor histocompatibility complexMHCResponse Evaluation Criteria in Solid Tumorschimeric antigen receptorT cell receptor
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Authors
David Chen, James Yang,