Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5685247 | Advances in Chronic Kidney Disease | 2016 | 4 Pages |
Abstract
Alternatives to the traditional parallel-group trial design may be required to answer clinical questions in special populations, rare conditions, or with limited resources. N-of-1 trials are a unique trial design which can inform personalized evidence-based decisions for the patient when data from traditional clinical trials are lacking or not generalizable. A concise overview of factorial design, cluster randomization, adaptive designs, crossover studies, and n-of-1 trials will be provided along with pertinent examples in nephrology. The indication for analysis strategies such as equivalence and noninferiority trials will be discussed, as well as analytic pitfalls.
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Authors
Joyce P. Samuel, Cynthia S. Bell,