Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5686980 | The Journal of Urology | 2017 | 5 Pages |
Abstract
Rabbit antiserum raised against the crude extract of normal human prostatic tissue contained antibodies to a prostatic tissue-specific antigen as shown by immunoprecipitation techniques. Using this antiserum a prostate antigen was detected in normal, benign hypertrophic, and malignant prostatic tissues, but not in other human tissues. The prostate antigen was purified to homogeneity from prostatic tissues and showed a single protein band on analytical polyacrylamide gel electrophoresis and isoelectric focusing. This report thus presents the first demonstration of the purification of a prostate-specific antigen that does not represent prostatic acid phosphatase.
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Authors
M.C. Wang, L.A. Valenzuela, G.P. Murphy, T.M. Chu,