| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5689131 | Early Human Development | 2016 | 7 Pages |
Abstract
Insulin-like growth factor 1 (IGF-1) acts to promote proliferation, maturation, growth and survival of neural cells. Low levels of circulating IGF-1 are associated with ROP and defects in the IGF-1 gene are associated with CNS disorders including learning deficits and brain growth restriction. Treatment of preterm infants with recombinant IGF-1 may potentially prevent ROP and CNS disorders. This review compares the role of IGF-1 in ROP and CNS disorders. A recent phase 2 study showed a positive effect of IGF-1 on the severity of IVH but no effect on ROP. A phase 3 trial is planned.
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Authors
Raffael MD, Chatarina PhD, Ann MD, PhD, Lois E.H. MD, PhD,