Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5691656 | European Journal of Obstetrics & Gynecology and Reproductive Biology | 2017 | 7 Pages |
Abstract
We have identified the immaturity of microvasculature and PB âassociated capillaries with a pathological persistency of immature CD15+/CD31+/CD34+ endothelial cells and a reduction of terminally differentiated CD15-/CD31+/CD34+ endothelial cells in a structurally and clinically heterogeneous group of high weight-placentas. We assume that immaturity of placental vessels are part of prenatal adaptational processes that can be recruited in different emergency situations and may provide potential targets of therapeutic correction of placental growth and chronic insufficiency. We therefore recommend the use of CD15-based immunophenotyping as a method to identify latent unfavorable conditions of fetal development in the intrauterine life and individual risk of disease in the postnatal period.
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Authors
L. Seidmann, Y. Kamyshanskiy, S.Z. Martin, A. Fruth, W. Roth,