Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5694247 | European Journal of Obstetrics & Gynecology and Reproductive Biology | 2017 | 23 Pages |
Abstract
Prochieve® possesses little biological activity to suppress delivery in a sensitive bioassay system and suggests that this preparation may be of little value in prevention and inhibition of preterm birth. Further, this study shows: 1) Inhibition of delivery is increased with P4 treatments when given subcutaneously or topically. 2) P4 in fish oil provides the best vehicle for topical treatment and may be an effective treatment of preterm birth. 3) P4 in fish oil also delays delivery even when treatment begins just prior to normal delivery. 4) To prevent preterm birth in pregnant women, randomized controlled studies are needed with a potent progestin using better formulations and routes of administration.
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Authors
Dajun Fang, Mario Moreno, Robert E. Garfield, Ruben Kuon, Huimin Xia,