Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5694984 | Fertility and Sterility | 2017 | 19 Pages |
Abstract
Mutations in genes implicated in cell-to-cell interactions and remodeling of the extracellular matrix and genomic aberrations involving genes coding for the Mediator complex subunits were identified in uterine leiomyomas. Additionally, we discovered that â¼4.6% of leiomyosarcomas harbored MED12 exon 2 mutations, but the relevance of this association with molecular pathogenesis of leiomyosarcoma remains unknown.
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Authors
Svetlana A. M.D., Priya Ph.D., Michelle A. Ph.D., Mirka W. M.D., Urvashi Ph.D., Robert P. M.D., Anil K. M.D., Aleksandar M.D., Ph.D.,