Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5695752 | Gynecologic Oncology | 2017 | 7 Pages |
Abstract
While cytotoxic T cells are present in tumor tissue to varying degrees, their density is lower than in peritumoral stroma, suggesting intratumoral exclusion or destruction of T cells. Higher densities of intratumoral macrophages compared to regulatory T cells suggest macrophages may be important contributors to the immunosuppressive tumor environment. Future directions for combination therapy include altering T cell trafficking and targeting tumor associated macrophages (TAMs) to enhance intratumoral activated T cell density and effect a more robust immune response.
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Authors
Kari L. Ring, Anna V. Yemelyanova, Pamela T. Soliman, Michael M. Frumovitz, Amir A. Jazaeri,