Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5696703 | Reproductive BioMedicine Online | 2017 | 8 Pages |
Abstract
In this prospective cohort study of 286 women undergoing fresh embryo transfer after IVF, uterine contraction frequency and direction were measured before (-5âmin), 5âmin after (+5âmin) and 60âmin after (+60âmin) embryo transfer. Mean ± SD uterine contraction frequency at â5âmin was 1.8 ± 1.1 contractions per min, increasing significantly (P < 0.05) to 2.0 ± 1.1 at +5âmin, and returning back to baseline 1.8 ± 1.1 at +60âmin. At â5âmin, the proportion of women the with retrograde, antegrade, indeterminate direction and absent contractions were 33%, 44%, 17% and 6%; at +5âmin, 40%, 42%, 13% and 5%, and at +60âmin, 42%, 38%, 14% and 6%. No significant change was observed in the proportion of direction at these three time points. Logistic regression analysis showed live birth rate was significantly reduced in older women (P = 0.035) and in those with higher uterine contraction frequency at +5âmin (P = 0.006). Frequency of uterine contraction immediately after embryo transfer (+5âmin) seemed to be a significant predictor of IVF outcome and may help to identify women who could benefit from the use of muscle relaxant therapy to improve outcome.
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Authors
Cathy Hoi Sze Chung, Alice Wai Yee Wong, Carol Pui Shan Chan, Sotirios H. Saravelos, Grace Wing Shan Kong, Lai Ping Cheung, Jacqueline Pui Wah Chung, Tin Chiu Li,