Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5696749 | Reproductive BioMedicine Online | 2016 | 7 Pages |
Abstract
This study explored the correlation between serum anti-Müllerian hormone (AMH) concentration and the number of retrieved oocytes after ovarian stimulation in Chinese infertile women undergoing assisted reproductive technology treatment and AMH cut-off values predicting low and high ovarian response. This was a prospective, multi-centre, observational study. A total of 615 subjects were included in nine assisted reproductive centres in China for outcome analysis. Subjects received assisted reproductive technology treatment and used recombinant human FSH (r-HFSH) or r-HFSH plus recombinant LH (rLH) for ovarian stimulation according to conventional treatment regimens. The main outcome variables were correlations between AMH and the number of retrieved oocytes and the cut-off values of AMH predicting low and high ovarian response. Serum AMH concentration was positively correlated with the number of oocytes retrieved in Chinese infertile women treated with IVF/intracytoplasmic sperm injection (ICSI) (Pearson correlation coefficient = 0.4754, P < 0.0001). The optimal AMH cut-off value was 2.6âng/ml (sensitivity: 81.28%, specificity: 59.51%) in predicting high and normal response, and 1.1âng/ml (sensitivity: 52.27%, specificity: 87.23%) in predicting low and normal response. In conclusion, serum AMH concentration can be used as a biomarker to predict ovarian response in Chinese infertile women treated with assisted reproductive technology.
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Authors
Rong Li, Fei Gong, Yimin Zhu, Wenhui Fang, Jing Yang, Jiayin Liu, Linli Hu, Dongzi Yang, Xiaoyan Liang, Jie Qiao,