Combined modality neoadjuvant treatment for stage III/IV melanoma with PD-1 blockade plus radiation: A case series

In this limited case series, our neoadjuvant combined modality regimen was effective and well tolerated. Concurrent PD-1 blockade with radiation therapy that could readily be applied into daily oncology practice is not limited in particular patient subgroups (e.g. BRAFV600-mutant) and may have a better toxicity profile than concurrent immune checkpoint blockade.