Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5697660 | Cancer Treatment Reviews | 2017 | 32 Pages |
Abstract
Through the introduction of a steadily growing variety of preclinical test models drug development and biomarker research has advanced. Next to classical used 2D cell line cultures, tissue-slice cultures, 3D organoid cell cultures, genetically engineered mouse models, cell line derived mouse models and patient derived xenografts may be selected for a specific question. All models harbor advantages and disadvantages. This review focuses on the available preclinical test models, novel developments such as humanized mice and discusses for which question a particular model should be employed.
Keywords
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Authors
Konrad Klinghammer, Wolfgang Walther, Jens Hoffmann,