Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5697900 | Clinical Oncology | 2016 | 8 Pages |
Abstract
In this cohort of rectal cancer patients dominated by T4 and advanced T3 cases given sequential oxaliplatin-containing preoperative therapy with acceptable toxicity, high tumour response rates and overall survival were obtained, consistent with both local and systemic effects. However, tumour response and long-term outcome remained inferior for a significant number of T4 cases, suggesting that the T4 entity is biologically heterogeneous with subgroups of patients eligible for further individualisation of therapy.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Oncology
Authors
S. Dueland, A.H. Ree, K.K. Grøholt, M.G. Saelen, S. Folkvord, K.H. Hole, T. Seierstad, S.G. Larsen, K.E. Giercksky, J.N. Wiig, K. Boye, K. Flatmark,