Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5698743 | Clinical Oncology | 2011 | 6 Pages |
Abstract
Cancer-induced bone pain (CIBP) is common and challenging to treat. Common therapies, such as opioids, radiotherapy and bisphosphonates, are often only partially effective. CIBP is a different entity to inflammatory or neuropathic pain and needs to be considered as such. This overview examines the mechanisms of CIBP; the imbalance of bone turnover, peripheral and central nervous involvement and key neurochemical mediators. The current understanding of the underlying pathophysiology of CIBP is discussed.
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Authors
T. Middlemiss, B.J.A. Laird, M.T. Fallon,