Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5699298 | Clinical Oncology | 2013 | 11 Pages |
Abstract
The field of high atomic number nanoparticle radiosensitising agents is reviewed. After a brief discussion of the new mode of physicochemical action implied by irradiation of high atomic number nanoparticles embedded in biological systems, a series of exemplars are discussed. Silver-, gadolinium- and gold-based nanoparticles are discussed in order of increasing atomic number with functionalisation strategies being outlined. In vitro and in vivo evidence for radio-enhancement and the mechanisms attributed to the increased biological effect are discussed.
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Authors
J.A. Coulter, W.B. Hyland, J. Nicol, F.J. Currell,