Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5699978 | Clinical Oncology | 2007 | 8 Pages |
Abstract
delE746-A750Â +Â L858R double activating EGFR mutations exist in Chinese NSCLC patients and both locate on the same allele. These patients tend to respond well to TKIs and the sensitivity to TKIs of this double mutated EGFR is enhanced compared with either single mutant. Nonetheless, the alteration in downstream signal transduction of the double mutant remains to be determined.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Oncology
Authors
G-C. Zhang, J-Y. Lin, Z. Wang, Q. Zhou, C-R. Xu, J-Q. Zhu, K. Wang, X-N. Yang, G. Chen, J-J. Yang, Y-J. Huang, R-Q. Liao, Y-L. Wu,