Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5701801 | Journal of Thoracic Oncology | 2016 | 16 Pages |
Abstract
T790M is likely a common resistance mechanism in patients treated with first-line afatinib. Although repeat biopsies at progression are crucial in elucidating resistance mechanisms, this study suggests that clinical and technical issues often limit their feasibility, highlighting the importance of developing noninvasive tumor-genotyping strategies.
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Authors
Meghan MD, David MD, Justin F. MD, Rebecca S. MD, MPH, Jennifer S. MD, Alice T. MD, PhD, Panos MD, Alona Muzikansky, Jeffrey A. MD, PhD, Lecia V. MD, MPH,