Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5702331 | Surgical Oncology | 2017 | 5 Pages |
Abstract
Our patient population had a relatively low rate of VTE as compared to the literature. Preoperative white blood cell count (WBC) and post-operative wound complications were both found to be independently associated predictors for VTE in patients with primary bone sarcoma. An elevated WBC may reflect hemoconcentration which per se is prothrombotic in nature. Aggressive DVT prophylaxis may, counter intuitively, increase the risk of thromboembolic events due to prolonged immobilization and additional surgeries that usually occur when addressing postoperative wound complications such as postoperative hematoma and wound dehiscence that may relate to overanticoagulation. Prospective randomized trials comparing different medications in combination with compressive devices are needed to assess efficacy with the lowest complication profile. Simpler protocols may increase patient compliance to prophylactic treatment.
Keywords
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Authors
Courtney L. Kaiser, Micayla K. Freehan, Daniel A. Driscoll, Joseph H. Schwab, Karen De Amorim Bernstein, Santiago A. Lozano-Calderon,