| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5705255 | Ophthalmology | 2017 | 12 Pages |
Abstract
Mutations in the CRB1 gene are associated with a spectrum of progressive retinal degeneration. Visual acuity survival analyses indicate that the optimal intervention window for subretinal gene therapy is within the first 2 to 3 decades of life.
Keywords
BCVAGVFffERGlogMARRetinitis pigmentosaFAFCrtCFCLeber congenital amaurosisLCAELMOctbest-corrected visual acuityOptical coherence tomographyGenetic isolatespectral-domaincentral retinal thicknessexternal limiting membranefundus autofluorescencelogarithm of the minimum angle of resolutionellipsoid zoneVisual field
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Authors
Mays MD, Mary J. MD, PhD, Maria M. MD, PhD, Jan PhD, Ralph J. PhD, Jacoline B. BAS, Nicoline E. MD, PhD, Gislin PhD, Frans P.M. PhD, Ron PhD, Marta PhD, Alberta A. MD, PhD, Carel B. MD, PhD, Caroline C. MD, PhD, Arthur A. PhD, Camiel J.F. MD, PhD,