Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5705707 | Progress in Retinal and Eye Research | 2017 | 40 Pages |
Abstract
Over the last decade, a large number of research articles have been published demonstrating regeneration and/or neuroprotection of retinal ganglion cells following manipulation of specific genetic and molecular targets. Interestingly, of the targets that have been identified to promote repair following visual system damage, many are genes known to be mutated in different types of cancer. This review explores recent literature on the potential for modulating cancer genes as a therapeutic strategy for visual system repair and looks at the potential clinical challenges associated with implementing this type of therapy. We also discuss signalling mechanisms that have been implicated in cancer and consider how similar mechanisms may improve axonal regeneration in the optic nerve.
Keywords
CNTFgp130STAT-3SOCS-3GAP-43EGFRGM-CSFhnRNP KNF-MAAVGBMRGCKLFSFPQLIFHHEXPI3KIL-6DLKDRGmTORHeterogeneous nuclear ribonucleoprotein Kdorsal root ganglionHCCJAK/STATinterleukin-6Axon regenerationEMTCNSdual leucine zipper kinasegrowth associated protein 43suppressor of cytokine signalling 3Retinal ganglion cellsretinal ganglion cellHepatocellular carcinoma cellscentral nervous systemleukemia inhibitory factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)ciliary neurotrophic factorphosphatase and tensin homologphosphatidylinositol-3-kinasegranulocyte macrophage-colony stimulating factorSignal transducer and activator of transcription-3mammalian target of rapamycinAdeno-associated virusretinoblastoma proteinPtencancer genesEpithelial-mesenchymal transitionGlioblastoma multiformeglycoprotein 130Epidermal growth factor receptor
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Authors
Amanda Barber, Kyle Farmer, Keith R. Martin, Patrice D. Smith,