Non-pharmacologic interventions for SCI patients: Hypertension and hypothermia

Spinal cord injury remains an important cause of disability worldwide. Current research efforts aim to limit the initial severity of injury, thereby reducing functional impairment. While a number of pharmacological agents are currently under consideration as potential neuroprotective agents, hypothermia and hypertensive therapy have also long been investigated for their potential value in this regard. In this article, we explore the existing preclinical and clinical evidence for the use of local and systemic hypothermia as well as hypertensive therapy in the context of acute traumatic SCI. In addition we will explore existing evidence gaps and opportunities for future research.