| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5715954 | Current Research in Translational Medicine | 2016 | 7 Pages |
Abstract
This review highlights the progress from the initial finding of neurogenic inflammation up to the most recent development in the field of sensory nerves research, focusing on their roles in the microvasculature and the skin. Recent discovery of Transient Receptor Potential (TRP) channels highlight their important roles in detecting a range of environmental stimuli, including chemical and temperature. This provides us novel mechanisms for driving neurogenic inflammation upstream of neuropeptide release in addition to promising potential therapeutic targets in various diseases, including pain, itching and skin inflammation.
Keywords
CFA4-ONEGastrin releasing peptide receptorIMQTSLPCLRNK1MrgprGRPRnNOSCGRPNGFPGE2NADPHTRPA1TRPV1DRGTrpRCPdorsal root ganglion4-oxo-2-nonenalcomplete Freund's adjuvantROSAdenosine TriphosphateATPSensory nervesSkin inflammationImiquimodinterleukinsPartumour necrosis factor alpharampneuronal nitric oxide synthasePeripheral vasculaturenerve growth factorTNF-αThymic stromal lymphopoietinSubstance Pknockoutneurokinin 1NeuropeptideswildtypeNitric oxidenicotinamide adenine dinucleotide phosphate (reduced form)transient receptor potentialtransient receptor potential ankyrin 1Transient receptor potential vanilloid 1protease activated receptorreceptor activity modifying proteinProstaglandin E2calcitonin gene related peptideTransient receptor potential channelsChloroquineReactive oxygen speciescalcitonin receptor-like receptor
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Authors
X. Kodji, A.A. Aubdool, S.D. Brain,