Article ID Journal Published Year Pages File Type
5716475 Human Pathology: Case Reports 2017 5 Pages PDF
Abstract

We report an anti-SV40 positive collecting duct (CD) cell carcinoma in a renal allograft 4.5 years after transplantation that developed during smoldering BK virus (BKV) nephropathy. In the allograft biopsy six months after transplantation documenting BK nephropathy, anti-SV40 positivity co-localized with the CD marker CK-HMW and proliferation marker MIB-1, suggesting that BKV preferentially infects CD cells and causes them to proliferate. In previous reports on BKV related renal malignancies, immunohistochemistry also pointed to a CD origin of the tumors. Six additional cases of BKV induced renal tumors were found in four CD carcinoma case-reports and one large case-series of “usual” CD carcinomas, supporting the hypothesis that BKV specifically induce CD cell tumor formation. In view of the rarity of BKV induced tumors a second hit might be needed to induce malignancy. In our case the use of lithium-which also causes CD cell proliferation-at the time of BKV infection may have provided this second hit.

Related Topics
Health Sciences Medicine and Dentistry Pathology and Medical Technology
Authors
, , , , , ,