| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5717052 | Academic Pediatrics | 2017 | 7 Pages |
ObjectiveTo assess whether asthma is associated with risk of appendicitis in children.MethodsWe used a population-based case-control study design using a comprehensive medical record review and predetermined criteria for appendicitis and asthma. All children (age younger than 18 years of age) who resided in Olmsted County, Minnesota, and developed appendicitis between 2006 and 2012 were matched to controls (1:1) with regard to birthday, gender, registration date, and index date. Asthma status was ascertained using predetermined criteria. Active (current) asthma was defined as the presence of asthma symptoms or asthma-related events (eg, medication use, clinic visits, emergency department, or hospitalization) within 1 year before the index date. Inactive asthma was defined as subjects without these events. A conditional logistic regression model was used.ResultsAmong the 309 appendicitis cases identified, when stratified according to asthma status, active asthma was associated with significantly increased risk of appendicitis compared with inactive asthma (odds ratio [OR]Â =Â 2.48; 95% confidence interval [CI], 1.22-5.03) and to no asthma (ORÂ =Â 1.88; 95% CI, 1.07-3.27; overall PÂ =Â .035). When controlling for potential confounders such as gender, age, and smoking status, active asthma was associated with a higher odds of developing appendicitis compared with nonasthmatic patients (adjusted ORÂ =Â 1.75; 95% CI, 0.99-3.11) whereas inactive asthma was not (overall PÂ =Â .049). Tobacco smoke exposure within 3 months was associated with an increased risk of appendicitis (adjusted ORÂ =Â 1.66; 95% CI, 1.02-2.69). Among asthma medications, leukotriene receptor antagonists reduced the risk of appendicitis (ORÂ =Â 0.18; 95% CI, 0.04-0.74).ConclusionsActive asthma might be an unrecognized risk factor for appendicitis in children whereas a history of inactive asthma does not pose such risk. Further investigation exploring the underlying mechanisms is warranted.
