| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5717118 | Anales de Pediatría | 2016 | 8 Pages |
Abstract
Leptomeningeal dissemination in paediatric central nervous system (CNS) tumours is associated with a poor outcome, and new therapeutic strategies are desperately needed. One of the main difficulties in the treatment of CNS tumours is blood brain barrier penetration. Intrathecal therapy has shown to be effective in several paediatric tumours. The aim of this article is to review the data available on the use of liposomal cytarabine for paediatric patients with leptomeningeal dissemination of CNS tumours, including the pharmacology, administration route, safety and efficacy data.
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Authors
Lucas Moreno, Miguel Angel GarcÃa Ariza, Ofelia Cruz, Carlota Calvo, Jose Luis Fuster, Jose Antonio Salinas, Cristina Moscardo, Raquel Portugal, Jose Manuel Merino, Luis Madero,