Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
57251 | Catalysis Today | 2009 | 7 Pages |
Abstract
A new insoluble polymer-bound bisoxazoline (IPB-box) was prepared by grafting a suitable chiral ligand derivative onto a commercial Merrifield resin. The material obtained by this route was employed in the asymmetric copper-catalyzed olefin cyclopropanation, obtaining good activity and enantioselectivity values (54–84% yield, 71–93% ee) for a range of substrates. In addition, some key factors required for the development of effective IPB-box systems are discussed, including the local ligand symmetry and the influence of immobilization technique and catalyst loading.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Alessandro Mandoli, Riccardo Garzelli, Simonetta Orlandi, Dario Pini, Marco Lessi, Piero Salvadori,