| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5725272 | Revue des Maladies Respiratoires Actualités | 2016 | 4 Pages |
Abstract
Alpha-B-crystallin is overexpressed in epithelial cells and myofibroblasts and is able to modulate the TGF-β pathway depending on the SMAD proteins. αB-crystallin is able to modulate the localization of SMAD 4 by inhibiting its ubiquitination. SMAD 4 stays in the nucleus and leads to collagen synthesis. Inhibition of HSP proteins is a new potential therapeutic target in fibrosis.
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Authors
C. Goyard, P. Bonniaud,