Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5728773 | Transplantation Proceedings | 2017 | 5 Pages |
ObjectivePlasma neutrophil gelatinase-associated lipocalin (pNGAL) is known to increase in proportion to the degree and period of renal damage. This study aimed to evaluate the clinical relevance of pNGAL and body adipose tissue to remaining renal function in living kidney donors.MethodsBetween July 2013 and February 2015, 75 live kidney donors were enrolled. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and VAT/SAT ratio were measured in preoperative CT scan which performed before surgery. We analyzed the correlation among the variables (VAT, SAT, and VAT/SAT ratio), eGFR and pNGAL. ÎpNGAL-max(=Maximum pNGAL-measures), ÎpNGAL-min(=Minimum pNGAL-measures), ÎeGFR-max(=Maximum eGFR-measures) and ÎeGFR-min(=Minimum eGFR-measures) were also analyzed.ResultsThe highest value of pNGAL (207.46 ± 76 ng/mL) was observed on postoperative day 7, and the lowest value of eGFR (57.52 ± 11.20 mL/min/1.73 m2) was also measured on postoperative day 7. A significant correlation was found between ÎpNGAL, VAT, and VAT-to-SAT ratio. Moreover, a significant correlation between ÎpNGALmin and ÎeGFRmin was revealed. Also, VAT-to-SAT ratio was correlated with ÎeGFRmin during the all of the follow-up periods, and it was also correlated with ÎpNGALmin until postoperative day 3.ConclusionThere was a correlation between the elevation of pNGAL until postoperative day 5 and the decrease of eGFR after living donor nephrectomy. VAT-to-SAT ratio had a significant correlation with both ÎpNGALmin and eGFRmin. Given the metabolism of pNGAL, the increase of pNGAL seemed to be affected as a consequence of body adipose tissue.