Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5728793 | Transplantation Proceedings | 2017 | 5 Pages |
BackgroundThis study investigated the prevalence of osteoporosis and the risk factors for its progression in kidney transplant recipients (KTRs).MethodsDual energy X-ray absorptiometry was used to prospectively measure changes in bone mineral density (BMD) before kidney transplantation (KT) and 1 year after transplantation in 207 individuals. We also analyzed the risk factors of osteoporosis progression during this period.ResultsPrior to KT, the mean BMD score (T-score of the femur neck area) was â2.1 ± 1.2, and the prevalence of osteoporosis was 41.5% (86/207). At 1 year post-transplantation, the mean BMD score significantly decreased to â2.3 ± 1.1 (P < .001), and the prevalence of osteoporosis increased to 47.3% (98/207; P = .277). The BMD score worsened over the study period in 69.1% (143/207) of patients, improved in 24.1% (50/207), and showed no change in 6.8% (14/207). Minimal intact parathyroid hormone (iPTH) improvement after KT was found to be an independent risk factor of osteoporosis progression.ConclusionsThis study demonstrates progressive loss of BMD after KT and sustained secondary hyperparathyroidism might influence the progression of osteoporosis.