4th Congress of the Spanish Society of TransplantationLiver transplantationRecurrent Hepatocellular Carcinoma After Liver Transplantation: Analysis of Risk Factors

•Tumor recurrence decreases survival after LT and is strongly associated with vascular invasion, capsular invasion, and tumor size.•Significant differences were found between patients with lowest histologic grade (Edmondson-Steiner G3-G4) and the development of tumor recurrence.•The survival of the patients who underwent LT for HCC in Hospital Universitario Virgen del Rocío was similar to the survival shown in the Registro Español de Trasplante Hepático.

BackgroundSurvival after orthotopic liver transplantation (LT) for hepatocellular carcinoma (HCC) is influenced by tumor recurrence. This study examines the survival of patients who underwent LT for HCC and developed recurrence of tumor after transplantation.MethodsA retrospective analysis was performed of the 200 patients who underwent LT secondary to HCC from 1990 to 2014. We excluded 19 patients from the study owing to early postoperative deaths in the 1st month. We divided our sample into 2 groups according to the presence of recurrence. We performed a univariate analysis to identify variables that are significantly associated with the risk of recurrence. Afterward we use multivariate analysis regression analysis to find independent significance.ResultsUnivariate analysis shows significant relationship between high Edmondson-Steiner grades (G3-G4) and the development of tumor recurrence. Tumor size, vascular invasion, and capsular invasion were found to be independent risk factors of tumor recurrence in the multivariate analysis.ConclusionsTumor recurrence defines survival of patients who underwent LT for HCC. In this study we discuss which histologic factor are associated with higher risk of tumor recurrence, and therefore a negative the impact on patient's survival.