| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5729054 | Transplantation Proceedings | 2016 | 4 Pages |
â¢Very few cases of IA of the gastric wall have been reported so far in the literature.â¢A unique case of a patient who in the course of an active dual fungal infection-IA and C krusei infection of the stomach wall-underwent OLT.â¢The patient was successfully treated with a combination therapy of voriconazole and caspofungin and her clinical condition continues to improve 9 months after liver transplantation.
Invasive aspergillosis (IA) is diagnosed almost exclusively in immunocompromised patients. It is located mainly in the lungs or paranasal sinuses, but occasionally other organs and the gastrointestinal tract may also be affected either alone or as a part of a disseminated disease. The main risk factors predisposing to IA are neutropenia, immunosuppressive and steroid therapy, as well as severe underlying disease. Despite progress in diagnostics and therapy of IA, it is still characterized by a high mortality rate. In the disseminated aspergillosis of the gastrointestinal tract, mainly the small or large intestine are affected, rarely the upper gastrointestinal tract. To our best knowledge only a very few cases of IA of the gastric wall have been reported so far in the literature. We describe a unique case of this very rare location of IA in the stomach in a patient who underwent orthotopic liver transplantation in the course of active IA and Candida krusei infection of the stomach wall. The patient's condition improved on combination therapy of voriconazole and caspofungin.
