| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5729156 | Transplantation Proceedings | 2016 | 5 Pages |
â¢The presence of both HBV and HDV does not significantly decrease the rate of recurrence.â¢A low recurrence rate was achieved by the prophylaxis protocol used at our center; moreover, none of our patients developed chronic hepatitis during the follow-up period.â¢There is no standard protocol for prevention of HBV and HDV recurrence; therefore, new studies are needed.
BackgroundIn this study, we retrospectively analyzed the recurrence of hepatitis B virus (HBV) and hepatitis D virus (HDV) infection after liver transplantation for HBV and HBV+HDV co-infection.MethodsData from patients infected with HBV and HBV+HDV who underwent liver transplantation between March 2003 and June 2013 at the Liver Transplantation Institute of Inonu University were analyzed retrospectively. A total of 255 patients were included in the study. Group 1 (n = 127) comprised patients who underwent liver transplantation because of HBV, and group 2 (n = 128) comprised patients who underwent liver transplantation because of HBV+HDV. A positive HDV antibody serologic test result was taken to indicate liver disease caused by HBV+HDV.ResultsThirteen of 255 were positive for the HBs Ag (5.1%). Nine (7.1%) and 4 (3.1%) patients were positive for the HBs Ag in groups 1 and 2, respectively (7.1%); the difference was not significant (P = .150). No HDV recurrence was detected in either group. The average time to HBs Ag seroconversion in 13 patients was 7.8 months after surgery (6.34 months in group 1 and 11.1 months in group 2).ConclusionsIn our study, recurrence rate of HBV after liver transplantation is not statistically different than the recurrence rate of HBV+HDV co-infection. A low recurrence rate was achieved by the prophylaxis protocol in use at our center. There is no standard protocol for prevention of HBV and HDV recurrence; therefore, we need new studies.
