| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5733795 | Journal of Surgical Research | 2017 | 7 Pages |
Abstract
The bone marrow microenvironment was significantly altered following severe trauma in a rodent model. Prohematopoietic cytokines were downregulated, and the proinflammatory cytokine HMGB-1 had increased bone marrow expression. Modulation of the bone marrow microenvironment may represent a therapeutic strategy following severe trauma to alleviate persistent injury-associated anemia.
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Authors
Jessica K. BS, Kolenkode B. PhD, Tyler J. MD, Ines G. MD, MPH, Jessica Plazas, Philip A. MD, Alicia M. MD,