| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5733849 | Journal of Surgical Research | 2017 | 9 Pages |
Abstract
PTH dose-dependently stimulates bone formation in vivo. However, during fracture healing, this did not result in a dose-dependent increase of the mechanical stiffness of the fracture callus. Taken together, our in vivo and in vitro data indicate that the dose-dependent effects of PTH during fracture healing are based on the actions on multiple cell types, thereby influencing not only bone formation but also osteoclastic callus remodeling.
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Authors
Alexander MD, Britta MD, Daniel MSc, Niklas MD, Richard MD, Thomas MD, Michael MD, Patric MD,