Ginsenoside Rg1 protects against sepsis-associated encephalopathy through beclin 1-independent autophagy in mice

These findings suggested that Rg1 improved the survival rate and ameliorated cognitive impairments partially through regulating cerebral inflammation and apoptosis. In addition, the action mechanism might be noncanonical beclin 1-independent autophagy pathway. Rg1 may be a promising treatment strategy for SAE.