BariatricEffects of Roux-en-Y gastric bypass on insulin secretion and sensitivity, glucose homeostasis, and diabetic control: A prospective cohort study in Chinese patients

BackgroundTo report on the effects of Roux-en-Y gastric bypass operation for obesity on measures of adiposity, insulin secretion and sensitivity, glucose homeostasis, and improvement in diabetic control in Chinese patients.MethodsThis was a prospective cohort study of 152 participants (81% with diabetes) who were recruited for bariatric operation.ResultsMean body mass index was decreased by 18.1% from 30.31 ± 5.38 kg/m2 at baseline to 24.45 ± 3.79 kg/m2 at 2 years (P < .001). Indices of insulin secretion, including serum c-peptide (both fasted and at various time points during an oral glucose tolerance test) improved at the 3-year follow-up, with a significant improvement in insulin sensitivity and glucose homeostasis.ConclusionThe effects of Roux-en-Y gastric bypass 3 years postoperative on adiposity were paralleled by a significant improvement in insulin secretion and sensitivity, and glucose tolerance.