Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5734582 | Surgery | 2017 | 11 Pages |
Abstract
Increased levels of proinflammatory cytokines, myeloperoxidase, and apoptosis are the hallmarks of acute respiratory distress syndrome. We noticed after intestinal ischemia-reperfusion the proinflammatory milieu in lungs was elevated significantly, while the CIRPâ/â mice had significantly decreased levels of proinflammatory cytokine, myeloperoxidase, and apoptotic cells leading to decreased lung injury. These findings strongly established a causal link between CIRP and acute respiratory distress syndrome during intestinal ischemia-reperfusion injuries. Targeting CIRP may therefore be beneficial for treatment of intestinal ischemia-reperfusion-associated acute respiratory distress syndrome acute respiratory distress syndrome.
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Authors
Cindy MD, Joseph MD, Monowar PhD, Weng-Lang PhD, Joaquin MD, Jeffrey M. MD, Gene F. MD, Ping MD,