Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5734650 | Surgery | 2017 | 12 Pages |
Abstract
Luminal flow in conjunction with short bowel syndrome significantly increases intestinal adaption within the proximal intestine in which proliferative cells contain β-catenin. Addition of an Igf1r inhibitor decreases adaptation in both proximal and distal limbs while increasing distal proliferative cells that do not colocalize β-catenin. Igf1r inhibition abrogates the increase in distal Sox9a expression that otherwise occurs in short bowel syndrome. Mechanoluminal flow is an important stimulus for intestinal adaptation.
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Authors
Kathy A. MD, Kathleen A. MD, Mubina MD, Christopher MD, Tasha BS, Thien BS, Justine W. PhD, Rex A. PhD, Harvey A. MD, Ching-Ling PhD, Kathryn MS, Xiaogang PhD, Rob PhD, Tracy C. MD,