Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5734847 | Surgery | 2017 | 7 Pages |
Abstract
Uncontrolled diabetes causes inactivation and reduction in the expression of endothelial adherens junction proteins in the arterioles of skeletal muscle early after cardiopulmonary bypass. The enhanced phosphorylation of vascular endothelial-cadherin and degradation of β-catenin indicate deterioration of these proteins and damage of the cell-cell endothelial junctions, specifically in the diabetic peripheral vessels. These alterations may contribute to the increases in peripheral vascular permeability and endothelial dysfunction.
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Authors
Jun MD, PhD, Yuhong MD, Arun K. MD, Afshin MD, Nicholas BS, Justin Liang, Frank W. MD,