Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5735020 | Behavioural Brain Research | 2018 | 8 Pages |
Abstract
The temporal distribution of extinction sessions did not affect the degree of extinction learning. However, only the rats that underwent the 7-day spaced extinction paradigm maintained the level of extinction in the long term, showing no SR in TWAA. This behavioural finding was consistent with a greater number of c-Fos-labelled neurons in the infralimbic cortex in the 7-day group, and in the Lateral and Central nuclei of the amygdala in the 24-hour group. These findings show that a time-spaced extinction paradigm reduces the spontaneous recovery of active avoidance behaviour, and that this behavioural advantage appears to be related to the activation of the infralimbic cortex.
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Authors
Carles Tapias-Espinosa, Elisabet Kádár, Pilar Segura-Torres,