Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5735063 | Behavioural Brain Research | 2017 | 11 Pages |
Abstract
These results indicate that the differences in the activity of the dopaminergic mesolimbic system in the HR and LR rats are maintained and even enhanced after a multi-day break in the use of the drug, indicating the occurrence of sensitisation. These findings show that the innate reactivity of the limbic dopaminergic innervations, dependent on the level of emotional reactivity, may significantly and chronically modify the development and maintenance of sensitisation to amphetamine.
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Authors
MaÅgorzata Lehner, Marek Gryz, Aleksandra WisÅowska-Stanek, Danuta TurzyÅska, Alicja Sobolewska, Anna Skórzewska, Adam PÅaźnik,