| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5735088 | Behavioural Brain Research | 2017 | 27 Pages |
Abstract
Our data suggest that cognitive deficits are first observed in the initial old stage. The levels of autophagy and apoptosis tend to be opposite in the adult and old phases. High levels of autophagy and apoptosis coexist in the initial old stage. Our study indicates that up-regulation of autophagy in the initial old phase to anti-cognitive deficits must be further evaluated.
Keywords
unc-51-like kinase 1NBPPI3KBeclin-1ACDmTORBcl-23-MALC3MWM3-methyladenineROSAktAutophagycornu ammonisBaxNMRApoptosislight chain 3AgingPhosphatidylinositol 3-kinaseB-cell lymphoma-2Morris water mazeNaked mole-ratmammalian target of rapamycinhematoxylin-eosinBcl-2 Associated X proteinprotein kinase BReactive oxygen species
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Authors
Yang Yu, Linjing Feng, Junnan Li, Xiaoxin Lan, Lixiang A, Xiaoyan Lv, Ming Zhang, Li Chen,