Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5735218 | Behavioural Brain Research | 2017 | 7 Pages |
Abstract
Deficits in social interaction are hallmarks of neurological and psychiatric disorders. However, its underlying mechanism is still unclear. Here, we show that the loss of dendritic cell factor 1 (Dcf1) in the nervous system of mice induces social interaction deficiency, autism-like behaviour, and influences social interaction via the dopamine system. Dopamine receptor D1 agonist rescues this social cognition phenotype, and improves short-term plasticity. Together, this study presents a new genetic mechanism that affects social interaction and may provide a new way to improve positive social interaction and treat autism spectrum disorders.
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Neuroscience
Behavioral Neuroscience
Authors
Qiang Liu, Jieyun Shi, Rongfei Lin, Tieqiao Wen,