Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5735231 | Behavioural Brain Research | 2017 | 9 Pages |
Abstract
In particular, there are several alterations in the aged brain that are amenable to being modeled genetically. We have focused on one key aspect that has been repeatedly demonstrated in aged animals - an increase in the L-type voltage-gated calcium channel CaV1.3. Here we present a novel transgenic mouse line in which expression of CaV1.3 is increased by approximately 50% in the forebrain of young mice. These mice do not display any overt physical or non-cognitive deficits, exhibiting normal exploratory behavior, motor function, and affective-like responses, suggesting that these mice can be successfully deployed to assess the impact of an “aged brain” in a variety of conditions.
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Authors
Jamie N. Krueger, Shannon J. Moore, Rachel Parent, Brandon C. McKinney, Amy Lee, Geoffrey G. Murphy,