Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5735453 | Behavioural Brain Research | 2017 | 16 Pages |
Abstract
Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.
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Authors
Iole Tomassini Barbarossa, M. Hakan Ozdener, Melania Melis, Latisha Love-Gregory, Makedonka Mitreva, Nada A. Abumrad, M. Yanina Pepino,